Landmark trial
Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases: final report of RTOG protocol 90-05
Shaw E, Scott C, Souhami L, et al. · RTOG
DoseLab summary
RTOG 90-05 dose-escalation study of single-fraction radiosurgery for previously irradiated brain tumors and metastases. It defined the maximum tolerated single dose by tumor diameter — 24 Gy up to 20 mm, 18 Gy for 21–30 mm and 15 Gy for 31–40 mm — which still shapes size-based SRS dose selection. Citation checked against Crossref.
Why this is useful
Why single-fraction SRS doses step down as the lesion gets larger.
Reference details
- Title
- Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases: final report of RTOG protocol 90-05
- Authors / organization
- Shaw E, Scott C, Souhami L, et al. · RTOG
- Publication / protocol
- Int J Radiat Oncol Biol Phys. 2000;47(2):291–298
- Version
- Pending verification
- Year
- 2000
- DOI
- 10.1016/S0360-3016(99)00507-6
- Disease sites
- CNS / Brain
- Topics
- SRS, Brain metastases, Dose escalation, Landmark trial
- Fractionation context
- Single fraction
- Last reviewed by DoseLab
- Pending verification