| Schedule | Constraint | Source |
|---|---|---|
| Conventional fractionation 70 Gy / 35 fx definitive · 60–66 Gy / 30–33 fx post-op | Mean ≤45 Gy | RTOG 0615 |
Glottic and supraglottic larynx, when it is not part of the target.
Quoted from eviQ 5049, checked 2026-09-24. Full table with references →
The voice box, below the hyoid bone and above the trachea, containing the supraglottis (epiglottis and false cords), the glottis (true vocal cords) and the subglottis.
The voice box. The vocal cords make the voice, and the larynx closes over the airway during swallowing so food and liquid do not go into the lungs.
Dose to the larynx can cause edema, hoarseness and swallowing problems. It is spared when the target is elsewhere — oral cavity, oropharynx, nasopharynx — and is part of the target in larynx cancer, where the limit does not apply.
Brouwer 2015 splits the larynx into two structures (Table 1), following Christianen 2011 for the supraglottic part.
Supraglottic larynx
Glottic area (the vocal cords and the fat around them, with the air left out)
RTOG 0920 instead defines a single glottic/supraglottic larynx (GSL) structure from just below the hyoid to the cricoid cartilage — check which your protocol uses.
Consensus CT delineation guidelines for head and neck organs at risk from eight cooperative groups, with anatomical descriptions and example images. Citation checked against Crossref; content not yet reviewed by DoseLab.
CT-based guidelines for delineating the organs at risk involved in swallowing. Citation checked against Crossref; content not yet reviewed by DoseLab.