GI · Organ at risk

Small Bowel

Educational Summary

Dose constraints

Esophagus & GE Junction

ScheduleConstraintSource
41.4 Gy / 23 fx
Preoperative
Avoid hotspotseviQ 1861
50.4 Gy / 28 fx
Definitive; also 50 Gy / 25 fx
Loops max <50 GyeviQ 1865

Quoted from eviQ 1861 and eviQ 1865, checked 2026-09-29. Full table with references →

Pancreas

ScheduleConstraintSource
50.4 Gy / 28 fx
45–54 Gy / 25–30 fx
Loops V15 Gy <120 ccQUANTEC summary
Bowel cavity V45 Gy <195 ccQUANTEC summary

Avoid hotspots. Each limit applies only to the contouring method it names.

Quoted from eviQ 3581, checked 2026-09-29. Full table with references →

Liver SBRT

ScheduleConstraintSource
42–54 Gy / 3 fx
Liver metastases
D0.1 cc ≤25.2 GyUK SABR consensus 2022
D5 cc ≤17.7 GyUK SABR consensus 2022
27.5–60 Gy / 5 fx
HCC or metastases
D0.1 cc ≤30 Gy (optimal), ≤35 Gy (mandatory)UK SABR consensus 2022
D10 cc ≤25 GyUK SABR consensus 2022

Quoted from eviQ 4026, checked 2026-09-29. Full table with references →

Rectum

ScheduleConstraintSource
45–50.4 Gy / 25–28 fx
Long course
V35 Gy <180 cc, V40 Gy <100 cc, V45 Gy <65 ccRTOG 0822
No volume ≥50 GyRTOG 0822
Bowel cavity V45 Gy <195 ccQUANTEC summary
25 Gy / 5 fx
Short course
Loops D200 cc <20 Gy, D20 cc <25 GyRCR rectal IMRT guidance
Bowel cavity D200 cc <23 GyRCR rectal IMRT guidance

Use the limits that match how you contour bowel — individual loops or the bowel cavity.

Quoted from RTOG 0822 and QUANTEC summary and RCR rectal IMRT guidance, checked 2026-09-29. Full table with references →

Anal Canal

ScheduleConstraintSource
50.4–54 Gy / 28–30 fx
Dose-painted IMRT
Loops V30 Gy <200 cc, V35 Gy <150 cc, V45 Gy <20 ccRTOG 0529
Max <50 GyRTOG 0529

An NRG template applies the same values to the whole bowel space.

Quoted from eviQ 1860, checked 2026-09-29. Full table with references →

Anatomy

The duodenum, jejunum and ileum. In the pelvis, loops of ileum are mobile and can drop down toward the bladder and seminal vesicles, especially when the bladder is empty or after pelvic surgery.

Function in the body

The small intestine absorbs most of the nutrients from food.

Why it matters

Small bowel matters most when the treated volume extends upward — pelvic lymph nodes, the prostate bed or large seminal vesicle volumes. For prostate-only treatment it is often far from the target, but a loop sitting just above the bladder can still come close. Acute effects include cramping and diarrhea; serious late effects such as obstruction are rare but significant.

In GI treatment small bowel is often the limiting organ: in rectal and anal cancer the elective nodal volumes rise into the pelvis where loops of bowel lie, and in pancreas and liver SBRT the bowel wraps around the target. The duodenum, the first part of the small bowel, has its own page.

In gynecologic treatment small bowel is usually the organ that limits the pelvic plan: the nodal volumes rise to the common iliac vessels or beyond, and after hysterectomy bowel loops often fall into the empty pelvis. NRG's GYN templates contour the bowel space (Spc_Bowel) — every slice from at least 2 cm above the PTV, including fat and mesentery — and a full bladder at simulation helps push bowel out of the field.

How to contour

Sources use two different approaches:

  • Individual loops. Gay 2012: oral contrast (given about 30 minutes before the scan) is encouraged so small bowel can be told from large bowel; the small bowel is outlined as the loops containing contrast. Jabbour 2014 recommends tracking the loops slice by slice.
  • Bowel bag. Gay 2012 also defines a "BowelBag": the abdominal contents (excluding muscle and bone) from the lowest small or large bowel loop or the top of the rectum, whichever is lower, with other organs subtracted. Jabbour 2014 does not recommend the bowel bag in place of individual loops for upper-abdominal planning.

Timmerman 2022 (Tables 8–11, written for its SBRT dose tables): all loops of small bowel within 10 cm of the PTV in any direction, as one structure.

A limit written for loops does not apply to a bowel bag, or the reverse — match the structure to your source.

Review articleSource Verified
A Story of Hypofractionation and the Table on the Wall
Timmerman R · UT Southwestern Medical Center · 2022

An editorial history of the UT Southwestern SABR constraint tables — often called the “Timmerman tables” — covering how they were developed and revised, and their relationship to AAPM TG-101 and NRG/RTOG protocols. Tables 2–11 separate serial tissues (listed with a volume, a volume max and a max point dose) from parallel tissues (listed with a critical volume and a critical-volume dose max). In Tables 2–7 a footnote defines “point” as ≤0.035 cm³; Tables 8–11 add a contouring-instructions column for each structure.

Further reading

  • QUANTEC — QUANTEC — Quantitative Analyses of Normal Tissue Effects in the Clinic Source
  • PACE-B — Intensity-modulated fractionated radiotherapy versus stereotactic body radiotherapy for prostate cancer (PACE-B): acute toxicity findings from an international, randomised, open-label, phase 3, non-inferiority trial Source
  • TROG NINJA — TROG 18.01 phase III randomised clinical trial of the Novel Integration of New prostate radiation schedules with adJuvant Androgen deprivation: NINJA study protocol Source
  • NRG cervix RT template — NRG Oncology Protocol Development Template for Radiation Therapy — Gynecological Cancer: Cervix, Uterine Cervix Source
  • NRG endometrial RT template — NRG Oncology Protocol Development Template for Radiation Therapy — Gynecological Cancer: Endometrial Cancer (post-operative treatment after hysterectomy) Source
  • EMBRACE II — The EMBRACE II study: The outcome and prospect of two decades of evolution within the GEC-ESTRO GYN working group and the EMBRACE studies Source

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